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Detectability of phencyclidine and
11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid in
adulterated urine by radioimmunoassay and fluorescence
polarization immunoassay.
Bronner W, Nyman P, von Minden D
Division of Forensic Toxicology, Armed Forces Institute
of Pathology, Washington, D.C. 20306-6000.
The ability to alter immunoassay test results by the
addition of some commonly available chemicals to
drug-positive and drug-negative urine specimens was
investigated. Urine specimens containing either
phencyclidine (PCP) or 11-nor-delta
9-tetrahydrocannabinol-9-carboxylic acid (9-THC-COOH)
were adulterated with sodium chloride, bleach, vinegar,
potassium hydroxide, liquid soap, 2-propanol, and
ammonia. Subsequent analyses by radioimmunoassay (RIA)
and fluorescence polarization immunoassay (FPIA)
demonstrated false positive and false negative results
with some adulterants. Radioimmunoassay false positives
occurred with potassium hydroxide (PCP and THC-COOH
assays) and bleach (THC-COOH assay) adulterants. Bleach
(PCP assay) and soap (THC-COOH assay) additives resulted
in false negative analyses by RIA. No adulterant caused
FPIA false positives. FPIA false negatives occurred with
bleach (PCP and THC-COOH assays) and potassium hydroxide
(PCP assay) adulterants.
PMID: 1964989, UI: 91203099
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