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Interference of common household
chemicals in immunoassay methods for drugs of abuse.
Warner A
Department of Pathology and Laboratory Medicine,
University of Cincinnati Medical Center, OH
45267-0714.
I report how some adulterants affect results for
drugs of abuse in urine as measured by Roche RIA,
Syva emit d.a.u., and Abbott TDx fpia (fluorescence
polarization immunoassay) for the following drugs:
amphetamines, barbiturates, benzodiazepines,
cannabinoids, cocaine, opiates, and phencyclidine
(PCP). Sodium chloride interfered negatively with
all of these drugs when assayed by emit and caused a
slight decrease in measured benzodiazepine
concentration by fpia. Drug concentrations were also
decreased by added H2O2 (emit: benzodiazepine), Joy
detergent (emit: cannabinoid, benzodiazepines, PCP),
NaHCO3 (emit: opiate; fpia: PCP), or NaClO
[corrected] (emit, RIA, fpia: amphetamines, opiates,
PCP; emit, fpia: cannabinoid; emit: benzodiazepines).
False-positive results were caused by H2O2 (fpia:
benzodiazepines) and Joy (RIA, fpia: benzodiazepine,
cannabinoid; fpia: barbiturate, amphetamine). Sodium
bicarbonate causes a suspiciously high pH in the
urine, NaClO [corrected] an apparently low pH (using
pH paper).
PMID: 2539273, UI: 89195648
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