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Efficacy of two commercial
products for altering urine drug test results.
Coleman DE, Baselt RC
Chemical Toxicology Institute Foster City, California
94404, USA.
OBJECTIVE: We have become aware of several commercial
products that, when orally ingested, will purportedly
not only eliminate "toxins" from a person's
system, but will also correct any urinary imbalances
caused by excessive water consumption.
METHOD: Unblinded
study of one volunteer subject, tested weekly x 4 for
24-hour urine elimination of test drug under conditions
of control, control plus 1200 mL water, Quick Flush',
and Eliminator.
RESULTS: Each of the treatment protocols
studied caused reductions of drug or metabolite
concentrations as measured by gas chromatography-mass
spectrometry in urine specimens collected up to 24 hours
after ingestion of amphetamine,
9-carboxy-11-nor-delta-9-THC, benzoylecgonine, or
codeine, yet the radioimmunoassay screening results
demonstrated very little effect. Water alone was
approximately as effective as the two commercial
products in reducing the metabolite level. None of the
treatment protocols employed in this study altered
urinary pH, specific gravity, or creatinine
concentration outside the normally accepted
physiological range.
Conclusions: Attempts to conceal
drug abuse by water dilution are most likely to play a
substantial role when concentrations are at or near the
detection threshold for a particular assay such as the
terminal stages of drug eliminations.
PMID: 9365433, UI: 98032137
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